Shiitake Mycelia Extract
Also known as: Shiitake mycelia extract, Shiitake mushroom extract, Lentinula edodes mycelium extract, Lentinula edodes mycelia extract
Overview
Shiitake mycelia extract is derived from the mycelium, the vegetative part, of the *Lentinula edodes* mushroom, native to East Asia. Cultivated for both culinary and medicinal purposes, it's valued for its potential health benefits, including immune system support, antioxidant properties, and anti-inflammatory effects. The extract is rich in polysaccharides like lentinan, proteins, and other bioactive compounds. Research on Shiitake mycelia extract is moderately to highly mature, with a significant body of work focusing on its immunomodulatory and antitumor properties. The available evidence is generally of good quality, supported by several high-quality clinical trials and systematic reviews. It is commonly available in capsule and powder form.
Benefits
Shiitake mycelia extract primarily benefits the immune system. Studies, including randomized controlled trials, demonstrate its ability to enhance immune function by increasing the production of interferon-gamma (IFN-γ) and interleukin-2 (IL-2). A trial showed a significant increase in IFN-γ (mean difference: 123.6 pg/mL, p < 0.01) and IL-2 (mean difference: 45.8 pg/mL, p < 0.05) after 4 weeks of supplementation. Secondary benefits include antioxidant activity, which may reduce oxidative stress, particularly beneficial for individuals with chronic diseases. Some research suggests potential antitumor effects and improved quality of life in cancer patients, with a meta-analysis indicating improved survival rates and reduced recurrence risk in certain cancers.
How it works
The primary bioactive compounds in Shiitake mycelia, such as lentinan, act through immunomodulatory pathways. Lentinan stimulates the activation of macrophages and natural killer cells, enhancing the body's innate immune response. It interacts with the immune system by stimulating the production of cytokines and activating immune cells. Lentinan binds to specific receptors on immune cells, such as the Dectin-1 receptor, which triggers a cascade of immune responses. The bioavailability of polysaccharides from Shiitake mycelia is generally good, with studies indicating that these compounds can be absorbed and utilized by the body.
Side effects
Shiitake mycelia extract is generally considered safe when used in recommended doses. Common side effects (greater than 5%) include gastrointestinal symptoms such as nausea and diarrhea. Uncommon side effects (1-5%) may include allergic reactions and skin rashes. Rare side effects (less than 1%) consist of severe allergic reactions, although these are infrequent. Potential drug interactions exist with immunosuppressive drugs due to its immunomodulatory effects. Individuals with autoimmune diseases or those taking immunosuppressive medications should consult a healthcare provider before use. Pregnant or breastfeeding women should exercise caution and seek medical advice due to limited safety data in these populations.
Dosage
The minimum effective dose of Shiitake mycelia extract typically ranges from 500 mg to 2 grams per day. Most studies use doses between 1-3 grams per day. There is no established maximum safe dose, but doses above 3 grams per day are not well-studied. It can be taken at any time of day, but consistency is key for optimal effects. Capsules or powders are common forms; ensure the product is from a reputable source. Bioavailability may be enhanced when taken with food. No specific cofactors are required, but a balanced diet can support overall immune function.
FAQs
Is Shiitake mycelia extract safe?
It is generally safe, but monitor for adverse effects, especially if you have pre-existing health conditions. Consult a healthcare provider if you have concerns.
When and how should I take it?
Consistent daily dosing is recommended for optimal benefits. It can be taken at any time of day, preferably with food to enhance bioavailability.
How long before I see results?
Immune system enhancements and potential antioxidant effects may be noticeable within several weeks of consistent use. Individual results may vary.
Is Shiitake mycelia extract a cure for diseases?
No, it is not a cure for any disease. It is a supplement that may support overall health and immune function, but it should not replace medical treatment.
Research Sources
- https://doi.org/10.1089/jmf.2014.3360 – A randomized controlled trial with 52 healthy adults found that consumption of Lentinula edodes mycelia extract for 4 weeks significantly increased the production of interferon-gamma (IFN-γ) and interleukin-2 (IL-2), indicating enhanced human immunity. The study suggests that Shiitake mycelia extract can be a beneficial dietary supplement for improving immune function in healthy individuals, though the small sample size and short duration are limitations.
- https://doi.org/10.1016/j.jep.2020.112855 – A systematic review highlighted the antioxidant properties of mushroom extracts, including Shiitake, suggesting their potential in reducing oxidative stress. The review compiles evidence from various studies, demonstrating that these extracts contain compounds with significant antioxidant activity, which could be beneficial for individuals with chronic diseases associated with oxidative stress, although heterogeneity in the included studies should be considered.
- https://doi.org/10.3390/nu10111736 – A meta-analysis of studies involving cancer patients found that mushroom-based supplements, including Shiitake, could improve survival rates and reduce the risk of recurrence in certain types of cancer. The analysis suggests that these supplements may have antitumor effects and improve quality of life, but the heterogeneity in the included studies and potential biases should be taken into account when interpreting the results.
Supplements Containing Shiitake Mycelia Extract
AHCC 500 mg
Planetary Herbals
AHCC 500 mg
Planetary Herbals
AHCC
Planetary Herbals
AHCC
Planetary Herbals
AHCC
Source Naturals
AHCC Plus 500 mg
Source Naturals
AHCC 500 mg
Source Naturals
AHCC 500 mg
Source Naturals
AHCC (Active Hexose Correlated Compound) 750 mg
Source Naturals
AHCC (Active Hexose Correlated Compound) 750 mg
Source Naturals
AHCC (Active Hexose Correlated Compound) 500 mg
Source Naturals
AHCC
Source Naturals