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Oil Of Oregano Extract

Also known as: oil of oregano, oregano oil, Origanum vulgare oil, carvacrol, thymol

Overview

Oil of oregano is an essential oil extracted from the leaves of the oregano plant, scientifically known as Origanum vulgare. Rich in phenolic compounds, particularly carvacrol and thymol, it is acclaimed for its potent antimicrobial and antioxidant properties. Oil of oregano is used in various applications, primarily for its antimicrobial, antifungal, and antiviral properties, making it popular in supporting digestive health and immune function. Characterized by strong antimicrobial activity against pathogens, it is utilized in both traditional and complementary medicine. Research on oil of oregano shows moderate maturity; while many in vitro and animal studies validate its effects, well-controlled human clinical trials remain limited. The quality of available evidence varies, being robust in some areas but less conclusive in others, particularly concerning human applications.

Benefits

Oil of oregano presents several evidence-based benefits: 1) **Antimicrobial Activity**: It shows significant antimicrobial activity against a wide range of bacteria, fungi, and viruses. A study found that carvacrol and thymol inhibited foodborne pathogens. 2) **Digestive Health**: Some evidence indicates it may alleviate symptoms of irritable bowel syndrome (IBS), with a small RCT demonstrating symptom reduction in patients. 3) **Antioxidant Activity**: Research has showcased its antioxidant properties that may protect against oxidative stress. 4) **Immune Support**: There are indications of immunomodulatory effects, but research in humans is sparse. Populations with gastrointestinal issues or those seeking natural antimicrobials may benefit most. Effect sizes are variable, with some studies showing moderate clinical significance.

How it works

Oil of oregano's primary activity stems from its key components, carvacrol and thymol, which disrupt microbial cell membranes and interfere with essential cellular processes. These compounds engage biological pathways through their interactions with membrane structures in bacteria and fungi, leading to increased permeability and ultimately microbial cell death. The antioxidants present also play a role in reducing oxidative stress and inflammation, benefiting various body systems, especially the gastrointestinal and immune systems.

Side effects

Oil of oregano is generally deemed safe when used appropriately and in moderation. Common side effects include gastrointestinal upset (nausea or stomach pain) occurring in over 5% of users. Less common side effects (1-5%) comprise allergic reactions and skin irritation. Rarely (less than 1%), severe allergic reactions may occur. It is advised to exercise caution in individuals taking blood thinners or diabetes medications due to potential interactions. Contraindications include pregnancy and breastfeeding, given the lack of sufficient safety data. Special populations, including children and elderly individuals, should use this supplement under medical supervision to mitigate risks.

Dosage

The minimum effective dose of oil of oregano typically ranges from 100 to 200 mg per day of the combined active compounds carvacrol and thymol. For specific applications, such as antimicrobial use, the recommended dosage range is 200 to 400 mg daily, while for digestive health, it is suggested to take 100 to 300 mg. It is generally not advised to exceed 600 mg per day without medical consultancy. Timing considerations include intake with meals, which may reduce gastrointestinal side effects. Capsules or softgels may provide better bioavailability, with absorption enhanced by consuming alongside fatty foods.

FAQs

How should oil of oregano be taken?

Oil of oregano is usually taken orally in capsule or liquid form, best with meals to minimize any gastrointestinal upset.

Is oil of oregano safe?

Generally safe, but it may cause gastrointestinal upset. Caution is advised during pregnancy, breastfeeding, or for those with allergies.

What are the expected results?

Antimicrobial effects can be rapid, while benefits for digestive health may take several weeks to notice.

Can oil of oregano interact with medications?

Yes, it may interact with blood thinners and diabetes medications; consulting with a healthcare provider is recommended.

Is oil of oregano a cure for infections?

No, it is not a cure-all. It should be used under medical guidance for serious conditions.

Research Sources

https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2672.2001.02427.x – This study demonstrates the minimum inhibitory concentration and mode of action of oregano essential oil, carvacrol, and thymol against foodborne pathogens, showcasing their strong antimicrobial properties.
https://www.ncbi.nlm.nih.gov/pubmed/10821753 – This RCT assessed oil of oregano's effect on IBS symptoms in patients, finding significant improvement after 6 weeks, indicating its potential in managing digestive health.
https://www.sciencedirect.com/science/article/abs/pii/S0278691504001060 – The study investigates the antioxidant capacity of oregano essential oil, revealing the beneficial effects of carvacrol and thymol against oxidative stress through various in vitro models.