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Velositol Amylopectin Chromium Complex

Also known as: Velositol, Amylopectin-Chromium Complex, ACr, Amylopectin Chromium Complex

Overview

Velositol is a patented dietary supplement ingredient composed of amylopectin and chromium, designed to enhance muscle protein synthesis (MPS) when combined with protein sources. Amylopectin is a branched-chain starch, and chromium is a trace mineral known for its role in insulin sensitivity. Velositol is primarily used in sports nutrition to improve muscle growth and strength gains, particularly in conjunction with resistance training. Research suggests that Velositol can increase the anabolic response to protein intake, making it a popular choice among athletes and fitness enthusiasts. It is available in various supplement forms, including powders and capsules, and is often added to protein shakes or pre-workout formulas. The available evidence is based on clinical trials demonstrating statistically significant effects on MPS and strength metrics.

Benefits

Velositol primarily enhances muscle protein synthesis (MPS) when combined with protein. Studies show that when combined with 6 grams of whey protein, Velositol increased MPS by 48% from baseline, compared to a 24% increase with whey protein alone. Another study indicated that adding Velositol to BCAAs increased MPS by 71% compared to the exercise control group, while BCAAs alone increased MPS by 57%. Secondary benefits include enhanced phosphorylation of mTOR signaling proteins (mTOR, S6K1, and 4E-BP1) and improved strength and power metrics, such as squat repetitions to failure and vertical jump power, over an 8-week resistance training period. These benefits are particularly noted in healthy, active individuals, with significant improvements in MPS and clinically relevant gains in strength and power.

How it works

Velositol enhances muscle protein synthesis (MPS) primarily by increasing insulin sensitivity through the action of chromium. This leads to a greater fractional rate of protein synthesis (FSR). It also activates the mTOR signaling pathway, a crucial regulator of protein synthesis and muscle growth. By influencing insulin levels and sensitivity, Velositol interacts with the endocrine system, affecting muscle protein kinetics. The supplement's effects are observed within hours of ingestion, suggesting good bioavailability. Key molecular targets include mTOR, S6K1, and 4E-BP1, all of which are essential proteins in the mTOR signaling pathway.

Side effects

The available studies indicate that Velositol is generally safe when used as directed. Clinical trials have not reported any significant adverse effects. However, due to its potential impact on insulin sensitivity and blood glucose levels, caution should be exercised in individuals with diabetes or those taking medications that affect blood glucose. There is limited information on drug interactions, but it may interact with medications affecting insulin sensitivity. No specific contraindications are mentioned in the studies, but consultation with a healthcare provider is advised for pregnant women, children, or individuals with chronic health conditions. Common, uncommon, and rare side effects have not been reported in studies to date.

Dosage

The minimum effective dose of Velositol appears to be 2 grams when combined with 6 grams of whey protein. Optimal dosage ranges include 2 grams of Velositol combined with a protein source such as 6-15 grams of whey protein or BCAAs. The maximum safe dose is not explicitly stated, but studies have not reported adverse effects at the doses used. Velositol should be consumed immediately after resistance training or at the same time of day on non-training days to maximize its effects. It is recommended to be taken in combination with a protein source, and adequate protein intake is necessary for its effects.

FAQs

How often should I take Velositol?

It should be taken immediately after resistance training or at the same time of day on non-training days to maximize its effects on muscle protein synthesis.

Can I take Velositol with other supplements?

There is no specific guidance, but caution is advised when combining with other supplements that affect insulin sensitivity or blood glucose levels.

Is Velositol safe for everyone?

It is generally safe for healthy, active individuals, but caution is advised for other populations, such as pregnant women or individuals with diabetes.

When should I take Velositol for best results?

For best results, take Velositol immediately after resistance training to enhance muscle protein synthesis and promote muscle growth.

Does Velositol work without exercise?

The benefits of Velositol are most pronounced when combined with resistance training, as it enhances muscle protein synthesis in response to exercise.

Research Sources

https://www.biospace.com/nutrition21-release-clinical-study-shows-velositol-doubles-power-of-protein-for-significantly-improved-muscle-protein-synthesis – This press release highlights a clinical study showing that Velositol doubles the power of protein for significantly improved muscle protein synthesis. The study indicates that Velositol enhances the effects of protein, leading to greater muscle growth and recovery.
https://pubmed.ncbi.nlm.nih.gov/28194093/ – This study investigated the effects of an amylopectin and chromium complex on muscle protein synthesis. The results showed that Velositol, when combined with whey protein, significantly increased muscle protein synthesis compared to whey protein alone, suggesting enhanced anabolic potential.
https://pubmed.ncbi.nlm.nih.gov/32460884/ – This animal study examined the impact of adding an amylopectin-chromium complex to BCAAs on muscle protein synthesis. The findings indicated that Velositol enhanced the effects of BCAAs, leading to increased muscle protein synthesis and activation of mTOR signaling proteins.
https://www.journalofexerciseandnutrition.com/index.php/JEN/article/view/94/80 – This study assessed the effects of an amylopectin-chromium complex plus whey protein on strength and power. The results demonstrated that Velositol combined with whey protein improved strength and power metrics, such as squat repetitions to failure and vertical jump power, over an 8-week period.