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Calcium Bisglycinate Chelate

Also known as: Calcium bisglycinate chelate, Chelated calcium, Amino acid chelated calcium

Overview

Calcium bisglycinate chelate is a mineral supplement where calcium is bound to two glycine molecules, enhancing its stability and absorption. This chelated form is designed to improve calcium uptake compared to traditional forms like calcium carbonate, as its absorption is less dependent on stomach acid. It is a manufactured compound and not found naturally in the diet. While research on calcium bisglycinate chelate specifically is still emerging, much of the evidence supporting its benefits is extrapolated from broader calcium supplementation studies. Calcium is crucial for bone health, muscle function, and various cellular processes. The bisglycinate form aims to optimize these benefits by increasing calcium's bioavailability.

Benefits

Calcium bisglycinate chelate primarily supports bone mineral density. Meta-analysis data indicates that calcium supplementation, in general, increases bone mineral density, particularly in younger individuals (≤35 years). Additionally, some research suggests a potential role in reducing colorectal cancer recurrence, although more specific studies are needed. The chelated form is designed for superior absorption compared to calcium carbonate, potentially maximizing these benefits. Calcium also plays a vital role in muscle function, contributing to excitation-contraction coupling. However, it's important to note that the direct evidence for these benefits specifically from calcium bisglycinate chelate is limited, and further research is needed to confirm these effects.

How it works

Calcium bisglycinate chelate enhances calcium absorption through glycine chelation, which prevents precipitation in alkaline environments, facilitating passive diffusion in the small intestine. This mechanism bypasses the need for stomach acid, unlike some other calcium forms. Once absorbed, calcium is incorporated into hydroxyapatite crystals in bones, a process regulated by parathyroid hormone. The chelation process is claimed to improve bioavailability compared to calcium carbonate, potentially leading to more efficient calcium utilization within the body. However, independent verification of these bioavailability claims is necessary.

Side effects

Common side effects of calcium bisglycinate chelate include constipation, although it is reported to have a lower incidence compared to calcium carbonate, and nausea. Rare risks include hypercalcemia, particularly at high doses (above 2,500 mg/day). Calcium can interact with other minerals like zinc and iron, potentially reducing their absorption. It can also enhance the toxicity of certain medications like digoxin and thiazide diuretics. Individuals with hypercalcemia or renal impairment should avoid calcium supplementation. It is crucial to adhere to recommended dosages and consult with a healthcare professional, especially if taking other medications or having pre-existing health conditions.

Dosage

The minimum effective dose of elemental calcium is generally considered to be 500-600 mg per day. An optimal range for supplementation is 800-1,200 mg per day, ideally split into multiple doses. The maximum safe dose, as per NIH guidelines, is 2,500 mg per day. Vitamin D (600-800 IU/day) is essential for calcium absorption and utilization. Calcium bisglycinate chelate can be taken without food, as its absorption is pH-independent. Individual needs may vary, so consulting with a healthcare provider is recommended to determine the appropriate dosage.

FAQs

Does it require food?

No, calcium bisglycinate chelate absorption is pH-independent, so it can be taken without food. This is a key advantage over some other calcium forms.

How long until results?

Changes in bone mineral density (BMD) typically require 6-12 months of consistent supplementation, as shown in RCT data. Individual results may vary.

Is it suitable for vegans?

Yes, calcium bisglycinate chelate is generally suitable for vegans, especially when plant-based capsules are used in commercial products. Always check the product label.

Research Sources

https://pmc.ncbi.nlm.nih.gov/articles/PMC6844170/ – This systematic review and meta-analysis of 43 RCTs (n=7,382) found that calcium supplementation increases bone mineral density in individuals aged 35 years or younger. The study highlights the importance of calcium for bone health, though it notes the heterogeneity of calcium formulations used in the included studies, meaning bisglycinate was not isolated.
https://pubmed.ncbi.nlm.nih.gov/36164828/ – This study investigated the impact of interventions on bone health. It provides insights into the effects of calcium supplementation on bone mineral density and overall bone health, contributing to the understanding of calcium's role in maintaining skeletal integrity.
https://www.mdpi.com/2072-6643/13/2/368 – This paper discusses the role of vitamin D and calcium in bone health. It highlights the importance of both nutrients for maintaining bone density and preventing osteoporosis, emphasizing the synergistic relationship between vitamin D and calcium in promoting skeletal health.
https://interplexus.com/pages/calcium2-datasheet-viewable – This datasheet provides information on the properties and benefits of calcium bisglycinate chelate. It highlights the enhanced bioavailability and absorption of this chelated form of calcium compared to other forms, suggesting improved efficacy in supporting bone health and other calcium-dependent functions. However, it's important to note that this source is from a manufacturer and may present a biased perspective.
https://www.kirkmangroup.com/products/calcium-bisglycinate-chelate-200-mg-without-vitamin-d-3-hypoallergenic – This product page describes a calcium bisglycinate chelate supplement. It emphasizes the hypoallergenic nature of the product and its potential benefits for individuals with sensitivities. However, as a product page, it should be considered a marketing material rather than a primary research source.