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Chasteberry Fruit Extract

Also known as: Chasteberry, Chaste Tree, Vitex agnus-castus

Overview

Chasteberry, derived from the fruit of the *Vitex agnus-castus* tree native to the Mediterranean, is a herbal supplement traditionally used to support female reproductive health. It contains flavonoids, terpenoids, and other bioactive compounds. Primarily, it is used to alleviate symptoms of premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD), regulate menstrual cycles, and address infertility issues. Research on chasteberry is moderately mature, with several randomized controlled trials and systematic reviews available. While some studies show positive effects on premenstrual symptoms, the overall quality of evidence is variable, and further high-quality research is needed to confirm these findings. It is available in forms such as capsules and tablets.

Benefits

Chasteberry is primarily known for reducing symptoms of premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD). A meta-analysis of fourteen studies indicated that thirteen reported positive effects on total premenstrual symptoms. It may also help with mastalgia and menstrual cycle regulation. The benefits are mainly observed in women experiencing PMS or PMDD, with studies showing a moderate reduction in symptoms typically within a few menstrual cycles. However, effect sizes vary across studies, highlighting the need for more consistent research methodologies.

How it works

Chasteberry interacts with opioid, dopamine, and hormone receptors, influencing prolactin release and menstrual cycle regulation. It primarily affects the reproductive and endocrine systems. Its known molecular targets include mu- and delta-opioid receptors, as well as dopamine receptors. While limited data exists on its bioavailability, the compounds in chasteberry are absorbed and exert systemic effects, contributing to its impact on hormonal balance and menstrual health.

Side effects

Chasteberry is generally well-tolerated in short-term use (up to 3 months). Common side effects include gastrointestinal issues, headache, and dizziness. Uncommon side effects may include allergic reactions and skin rashes. Drug interactions are possible with dopamine agonists, antipsychotics, and potentially hormonal contraceptives. It is contraindicated in pregnancy, breastfeeding, and certain endocrine disorders. Special populations, such as children and individuals with hormone-sensitive conditions, should avoid its use. It's important to consult with a healthcare provider before use, especially if taking other medications, and to monitor for any adverse effects.

Dosage

The typical recommended dosage of chasteberry is 20-40 mg of dried fruit extract per day, standardized to contain specific flavonoids. It is often taken daily throughout the menstrual cycle. Capsules or tablets are common forms. The maximum safe dose is not well-established, and it is generally not recommended to use it beyond 3 months without medical supervision. Bioavailability may vary based on the formulation. Consult a healthcare provider for personalized dosage recommendations.

FAQs

How long does it take to see results from taking Chasteberry?

Symptom reduction may be noticeable within a few menstrual cycles. However, individual responses can vary, and consistent daily use is typically recommended for optimal results.

Is Chasteberry safe to take with other medications?

Consult a healthcare provider before use, especially if taking other medications, as potential interactions exist with dopamine agonists, antipsychotics, and hormonal contraceptives.

What are the common side effects of Chasteberry?

Common side effects include gastrointestinal issues, headache, and dizziness. Monitor for any adverse effects and discontinue use if severe reactions occur.

Can Chasteberry be used as a substitute for medical treatment?

No, Chasteberry is not a substitute for medical treatment. Efficacy varies among individuals, and it's essential to consult with a healthcare provider for appropriate medical advice.

Who should avoid taking Chasteberry?

Chasteberry is contraindicated in pregnancy, breastfeeding, and certain endocrine disorders. Children and individuals with hormone-sensitive conditions should also avoid its use.

Research Sources

https://www.nccih.nih.gov/health/chasteberry – This resource from the National Center for Complementary and Integrative Health (NCCIH) provides general information about chasteberry, including its uses, potential side effects, and precautions. It serves as a reliable starting point for understanding the basics of chasteberry and its role in health.
https://pubmed.ncbi.nlm.nih.gov/28237870/ – This PubMed entry links to a study or review about chasteberry. Further investigation of the linked article will provide specific details on the study design, results, and conclusions regarding chasteberry's effects.
https://womensmentalhealth.org/posts/chasteberry-for-pms-and-pmdd/ – This resource discusses the use of chasteberry for premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD). It likely provides insights into the effectiveness and appropriate use of chasteberry for these conditions, targeting women's mental health.
https://www.mskcc.org/cancer-care/integrative-medicine/herbs/chasteberry – Memorial Sloan Kettering Cancer Center provides information on chasteberry as part of their integrative medicine resources. This source likely covers the uses, potential benefits, and precautions related to chasteberry, with a focus on its role in cancer care and integrative health practices.
https://www.thieme-connect.com/products/ejournals/pdf/10.1055/s-0032-1327831.pdf – This systematic review evaluated the efficacy and safety of *Vitex agnus-castus* extracts in female reproductive disorders. It highlights the need for well-designed studies to confirm benefits, emphasizing the importance of rigorous research in understanding chasteberry's effects.
– Verkaik et al. conducted a meta-analysis that included 14 RCTs examining *Vitex agnus-castus* for PMS and PMDD. Thirteen of these studies reported positive effects on total premenstrual symptoms, suggesting a potential benefit of chasteberry in alleviating these conditions.
– Cerqueira et al. performed a systematic review analyzing eight RCTs, all of which showed positive effects on PMS or PMDD symptoms. However, the results were heterogeneous due to varying diagnostic criteria and symptom assessment tools, indicating a need for standardized research methodologies.