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Coleus Root Extract

Also known as: Coleus root extract, forskolin, Coleus, Plectranthus barbatus, Coleus forskohlii

Overview

*Coleus forskohlii* is a perennial plant indigenous to India and Southeast Asia, known for its roots that contain the bioactive compound forskolin. This compound has been historically utilized in Ayurvedic medicine to address various health issues, including heart ailments, asthma, and digestive complications. In contemporary health contexts, *Coleus forskohlii* has risen in popularity for its potential benefits in weight management and promoting bone health. Forskolin works primarily by increasing levels of cyclic adenosine monophosphate (cAMP) within cells, which can influence numerous physiological functions. Although research surrounding this supplement is developing, some studies offer compelling evidence of its efficacy, signaling the need for further investigation into its broader health impacts.

Benefits

Research demonstrates several beneficial effects of *Coleus forskohlii*, particularly in supporting weight management and bone health. In a randomized controlled trial, participants taking the supplement experienced improvements in insulin sensitivity and reductions in waist and hip circumference after a 12-week period. Animal studies indicate potential for preserving bone density and strength, making it particularly relevant for post-menopausal women. While there is some evidence relating to cardiovascular health and asthma management, these areas require additional studies for confirmation. Overall, significant clinical effects are recorded, yet comprehensive systematic reviews are needed for more robust conclusions.

How it works

Forskolin primarily operates by activating adenylate cyclase, thus raising intracellular cAMP levels. This increase in cAMP is pivotal for regulating various biological processes, impacting metabolism and bone formation. By elevating cAMP concentrations, forskolin effectively influences several body systems, modulating metabolic rates, and engaging cellular signaling pathways critical for maintaining bone health.

Side effects

When used appropriately, *Coleus forskohlii* is generally deemed safe; however, some individuals may experience side effects. Commonly reported issues include gastrointestinal discomfort, such as upset stomach and nausea. Less frequent side effects, occurring in 1-5% of users, include headaches and dizziness. Rare adverse effects (less than 1%) may involve hypotension and allergic reactions. Users on anticoagulants or antiplatelet drugs, as well as those with diabetes or hypertension, should exercise caution due to potential interactions. Pregnant or breastfeeding individuals and those with certain cardiovascular conditions are advised against using this supplement. People with bleeding disorders or those on conflicting medications should also consult healthcare providers before use.

Dosage

Typically, the minimum effective dose for *Coleus forskohlii* extract is around 250 mg per serving, standardized to contain at least 10% forskolin content. The suggested daily dosage commonly ranges from 250 mg to 500 mg, with most evidence supporting this intake level for achieving desired effects. Caution is advised for doses exceeding 500 mg, as upper limits are not well-defined. For optimal results and to reduce gastrointestinal discomfort, taking forskolin with meals is recommended. Capsules and tablets are common forms for consumption, and absorption may be enhanced when taken with dietary fats, although further investigation into necessary cofactors is warranted.

FAQs

Is *Coleus forskohlii* safe?

Generally considered safe, it may interact with certain medications, so consulting a healthcare provider is recommended.

When is the best time to take *Coleus forskohlii*?

It is best taken with meals to minimize gastrointestinal discomfort.

How long does it take to see results?

Improvements in weight management and bone health are often noticeable within several weeks to months.

Can I expect quick weight loss from *Coleus forskohlii*?

It is not a quick solution; for optimal results, it should be combined with a healthy diet and exercise.

Research Sources

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4442468/ – This systematic review assesses the efficacy of forskolin in weight management, noting significant improvements in body composition metrics such as fat mass and waist circumference in overweight populations. The study emphasizes the need for larger, more robust trials to validate these findings.