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Leucoselect Grape Seed Proanthocyanidin Extract

Also known as: Leucoselect Phytosome®, GSE, grape seed procyanidins, Vitis vinifera proanthocyanidin extract

Overview

Leucoselect is a patented grape seed extract derived from *Vitis vinifera* seeds, utilizing phytosome technology to enhance bioavailability. It is standardized to contain at least 75% oligomeric proanthocyanidins (OPCs), which are polyphenolic compounds known for their antioxidant properties. The phytosome complex involves binding the extract to phospholipids, which improves its absorption in the body compared to standard grape seed extracts. Research suggests potential benefits in cardiovascular and pulmonary health, primarily attributed to its antioxidant and anti-inflammatory effects. However, it's important to note that current evidence is based on preliminary studies and small-scale human trials. Leucoselect is available in capsule form and is often marketed as a dietary supplement for overall health and well-being. Further research is needed to fully establish its efficacy and safety profile.

Benefits

Leucoselect grape seed proanthocyanidin extract exhibits several potential health benefits, primarily related to its antioxidant and anti-inflammatory properties. A small randomized controlled trial (RCT) demonstrated an approximately 11% increase in serum total antioxidant activity within 5 days of supplementation in healthy volunteers. Preclinical studies suggest anti-inflammatory effects, specifically reducing TNF and CCL3 levels in the lung microenvironment. Some mechanistic studies indicate potential vascular protection, although human RCTs with sufficient sample sizes are lacking. A pilot study showed antineoplastic potential in lung cancer patients, but the methodology was unclear and lacked a control group. Overall, the evidence for these benefits is preliminary, and larger, well-designed clinical trials are needed to confirm these findings.

How it works

Leucoselect works through several mechanisms, primarily related to its high concentration of oligomeric proanthocyanidins (OPCs). These OPCs act as free radical scavengers, directly donating electrons to neutralize reactive oxygen species and reduce oxidative stress. Preclinical studies suggest that Leucoselect may also modulate CYP3A4 activity in the lungs, potentially influencing the metabolism of various compounds. The phytosome formulation enhances the absorption of OPCs compared to standard grape seed extracts, improving its bioavailability. These combined actions contribute to its antioxidant and anti-inflammatory effects, potentially benefiting cardiovascular and pulmonary health.

Side effects

Leucoselect is generally considered safe, but some side effects have been reported. The most common side effect is mild gastrointestinal discomfort, which appears to be dose-dependent. Rare allergic reactions may occur in individuals sensitive to grapes. There is a theoretical risk of interactions with drugs metabolized by CYP3A4, although this has not been extensively studied in humans. Due to insufficient data, Leucoselect is classified as Pregnancy Category N, indicating caution during pregnancy. It is advisable to start with a low dose and monitor for any adverse effects. Individuals taking medications or with known allergies should consult with a healthcare professional before using Leucoselect.

Dosage

The effective dosage range for Leucoselect is typically between 150-300mg daily. Some studies have used up to 600mg per day for short durations. It is recommended to take Leucoselect with meals to optimize absorption. The phytosome complex form is preferred due to its enhanced bioavailability compared to standard grape seed extracts. While specific upper limits have not been definitively established, it is prudent to adhere to the recommended dosage range and consult with a healthcare professional for personalized guidance. Dosage may vary depending on the intended use and individual factors.

FAQs

How long until effects appear?

Antioxidant effects may be measurable within 5 days, as shown in studies. However, clinical outcomes may require several weeks of consistent use to become noticeable.

Are there any synergistic combinations?

Vitamin C may enhance the stability of Leucoselect, although there is no robust RCT evidence to support this. Combining with other antioxidants may provide additive benefits.

What is the difference from regular GSE?

The phytosome complex in Leucoselect shows approximately 2-3 times greater absorption compared to regular grape seed extract, leading to potentially enhanced bioavailability and effects.

Research Sources

https://pubmed.ncbi.nlm.nih.gov/39684816 – This preclinical study investigated the pulmonary effects of Leucoselect in a lung microenvironment model. The findings indicated a reduction in TNF and CCL3 levels, suggesting anti-inflammatory properties. Additionally, the study showed modulation of CYP3A4, a cytochrome P450 enzyme, which could have implications for drug metabolism in the lungs.
https://pubmed.ncbi.nlm.nih.gov/31138523/ – This uncontrolled pilot study examined the potential of Leucoselect as an adjuvant treatment in lung cancer patients. While the study reported reduced cancerization markers, the lack of a control group and unclear methodology limit the strength of the findings. Further research with a more rigorous design is needed to confirm these preliminary results.
https://www.jstage.jst.go.jp/article/jhs/49/1/49_1_45/_article – This article discusses the enhanced absorption of Leucoselect due to its phytosome formulation. The phytosome complex improves the bioavailability of the proanthocyanidins, allowing for greater uptake and utilization by the body. This enhanced absorption is a key advantage of Leucoselect over standard grape seed extracts.
https://www.thorne.com/products/dp/o-p-c-100-trade – This is a product page for Thorne's OPC-100, which contains grape seed extract. It highlights the antioxidant properties of OPCs and their potential benefits for cardiovascular health. The page also mentions the importance of bioavailability and absorption for optimal effectiveness.
https://pubmed.ncbi.nlm.nih.gov/9875688/ – This single-blind crossover study (n=20) investigated the antioxidant effects of Leucoselect at a dose of 600mg/day for 5 days. The results showed an increase in total antioxidant capacity without affecting vitamin C or E levels. The study was limited by its small sample size and short duration, but it provides evidence for the antioxidant activity of Leucoselect.