Get Your Personalized Supplement StackSupplement Stack Quiz

Methyliberine

Also known as: Methylliberine, Dynamine®

Overview

Methylliberine, commonly known by its brand name Dynamine®, is a purine alkaloid often synthesized for use in dietary supplements. It is primarily used to enhance energy, focus, concentration, and mood. Similar to caffeine and theacrine, methylliberine acts as an adenosine receptor antagonist but has a shorter half-life. Research on methylliberine is relatively limited compared to more established stimulants, but available studies, including randomized controlled trials and within-subject crossover designs, suggest potential benefits. It is found to improve concentration, motivation, and mood without significantly affecting vital signs or cognitive function. Methylliberine reaches peak plasma concentrations at 0.8–0.9 hours and has a half-life of 1.4–1.5 hours.

Benefits

Methylliberine has been shown to improve concentration, motivation, and mood. A double-blind, randomized, within-subject crossover trial found that 100 mg of methylliberine significantly improved concentration at 1 and 3 hours, motivation at 3 hours, and mood at 1, 2, and 3 hours (p ≤ 0.050). Women in the study also experienced elevations in sustained energy at 1 and 3 hours compared to placebo (p ≤ 0.050). Additionally, methylliberine improved well-being and the ability to tolerate stress to a greater extent than the placebo at 3 hours. These benefits were observed in both men and women, with specific improvements in sustained energy noted in women. The effects are noticeable as early as 1 hour post-ingestion and can last up to 3 hours.

How it works

Methylliberine primarily functions as an adenosine receptor antagonist, which can increase dopamine transmission and impact behavioral activation and effort-related processes. By modulating adenosine receptors in the central nervous system, it leads to increased alertness and energy. Its primary molecular targets are adenosine A1 and A2 receptors. Methylliberine reaches peak plasma concentrations at 0.8–0.9 hours and has a half-life of 1.4–1.5 hours, indicating relatively rapid absorption and elimination from the body.

Side effects

Methylliberine appears to be safe when consumed in studied doses (25 mg and 100 mg). No common, uncommon, or rare side effects were reported in the reviewed studies. However, methylliberine can reduce the oral clearance and extend the half-life of caffeine when co-administered, although caffeine does not affect the pharmacokinetics of methylliberine. There are no specific contraindications identified in the available literature, and studies have not included special populations such as pregnant women, children, or individuals with chronic health conditions. More extensive and long-term studies are needed to fully understand its effects and potential interactions.

Dosage

The minimum effective dose of methylliberine appears to be around 100 mg, based on available studies. While the optimal dosage range is not fully established, 100 mg has shown significant effects without adverse events. The maximum safe dose has not been definitively established, but doses up to 100 mg have been used without adverse effects. Benefits are observed as early as 1 hour post-ingestion and last up to 3 hours. Peak plasma concentrations are reached at 0.8–0.9 hours. There is no evidence suggesting the need for specific cofactors.

FAQs

How long does it take to feel the effects?

The effects of methylliberine are observed as early as 1 hour post-ingestion, providing a relatively quick onset of action.

Is it safe to use with other stimulants?

Methylliberine can be used with caffeine but may extend the half-life of caffeine. It does not significantly increase heart rate or blood pressure when used alone or in combination with caffeine and theacrine.

What are the potential side effects?

No significant side effects were reported in the studies reviewed, suggesting it is generally well-tolerated at studied doses.

How long do the benefits last?

The benefits of methylliberine, such as improved concentration and mood, can last up to 3 hours post-ingestion.

Does methylliberine improve cognitive function?

Methylliberine does not significantly impact cognitive function tests, but it can improve subjective feelings of concentration and motivation.

Research Sources

https://www.mdpi.com/2072-6643/15/21/4509 – This double-blind, randomized, within-subject crossover trial involving 25 healthy adults found that methylliberine (100 mg) improved concentration, motivation, and mood without affecting cognitive function or vital signs. The study highlights the potential of methylliberine as a supplement for enhancing subjective feelings of energy and focus.
https://www.memphis.edu/nutraceutical/pdfs/12-2020-mra-methylliberine-safety.pdf – This study assessed the acute impact of methylliberine alone or in combination with caffeine and/or theacrine in 12 healthy adults. The results indicated that methylliberine did not result in significant increases in heart rate, blood pressure, respiratory rate, or body temperature, suggesting a favorable safety profile.
https://esmed.org/MRA/mra/article/view/2062 – This article discusses the safety of methylliberine, noting that it does not significantly affect vital signs such as heart rate and blood pressure. It also mentions that methylliberine can be safely combined with caffeine and theacrine without causing adverse effects on cardiovascular function.
https://training.cochrane.org/handbook/current/chapter-04 – This Cochrane handbook chapter provides guidance on conducting systematic reviews, which are essential for synthesizing evidence on the effectiveness and safety of interventions like methylliberine. It emphasizes the importance of rigorous methodology and transparent reporting to ensure the reliability of review findings.
https://subjectguides.lib.neu.edu/systematicreview/databases – This resource lists databases relevant for conducting systematic reviews, which are crucial for evaluating the evidence base for supplements like methylliberine. It helps researchers identify and access relevant studies to assess the efficacy and safety of methylliberine comprehensively.