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Phlomis Umbrosa Root Extract

Q: Is Phlomis umbrosa safe for human use?

The safety of Phlomis umbrosa in humans is not well-established, necessitating further research before considering it as a safe supplement.

Q: When should I take Phlomis umbrosa?

There is currently no specific guidance on timing or administration for humans, as detailed recommendations are not available.

Q: What results can I expect from using Phlomis umbrosa?

While it has shown potential in increasing longitudinal bone growth in animal studies, human results remain unverified due to a lack of clinical data.

Q: Are there common misconceptions about Phlomis umbrosa?

It is often regarded as inherently safe based on traditional usage, but actual efficacy and safety must be confirmed via clinical trials.

Also known as: Phlomis umbrosa root extract, Lamiaceae family plant, East Asian traditional medicine herb, Phlomis umbrosa

Overview

Phlomis umbrosa is a flowering plant belonging to the Lamiaceae family, primarily found in East Asia. Traditionally utilized in Asian medicine, this herb has gained attention for its potential to enhance bone health and its anti-inflammatory properties. The root extract contains bioactive compounds like shanzhiside methyl ester, chlorogenic acid, and caffeic acid, which are credited for its biological activities. Preclinical studies conducted in animal models have shown encouraging results, particularly in enhancing bone growth, yet concrete evidence from human trials is lacking. Consequently, while the extract is promising for therapeutic applications, there is a need for more robust data, especially concerning safety and efficacy parameters within human populations.

Benefits

Research indicates that Phlomis umbrosa root extract may primarily promote bone growth. An animal study that administered 1000 mg/kg to adolescent rats demonstrated significant increases in proximal tibial length and enhanced levels of growth factors IGF-1 and BMP-2 (p < 0.05). The claimed anti-inflammatory properties have yet to be adequately quantified in relation to their impact on bone growth. The benefits seem to be most relevant for younger demographics, according to current preclinical research, although the studies are limited to animal models. More extensive research is urgently needed to validate these benefits in human subjects and explore any potential therapeutic applications.

How it works

The action of Phlomis umbrosa is thought to involve the growth hormone axis, with key growth factors such as IGF-1, BMP-2, and IGFBP-3 playing crucial roles. The bioactive components in the extract may enhance the signaling pathways critical for osteogenesis, thereby promoting healthy bone formation and maintenance. However, the exact molecular interactions and bioavailability in humans remain largely unknown due to insufficient clinical studies.

Side effects

The safety profile of Phlomis umbrosa root extract remains inadequately defined in humans because of limited clinical research. While animal studies suggest it is generally well tolerated and no common side effects have been reported, the absence of adverse reactions does not imply inherent safety, especially for vulnerable populations (e.g., pregnant or breastfeeding women, children, or individuals with chronic illnesses). There is also currently no data available regarding potential drug interactions or contraindications. It is important to approach the usage of this extract with caution and await further safety assessments before widespread human consumption.

Dosage

Available research, particularly from animal studies, indicates that a dosage of 1000 mg/kg is effective for promoting bone growth over a 10-day period. However, there are no established optimal dosages for human use, largely due to the lack of clinical trials. Furthermore, literature does not provide maximum safe dosages or specific timing recommendations for administration. The extract is typically taken orally during research, but factors affecting its absorption and the need for any cofactors are not well defined. Given the current uncertainties, caution is advised until further data regarding safe dosages for human consumers is made available.

FAQs

Is Phlomis umbrosa safe for human use?

The safety of Phlomis umbrosa in humans is not well-established, necessitating further research before considering it as a safe supplement.

When should I take Phlomis umbrosa?

There is currently no specific guidance on timing or administration for humans, as detailed recommendations are not available.

What results can I expect from using Phlomis umbrosa?

While it has shown potential in increasing longitudinal bone growth in animal studies, human results remain unverified due to a lack of clinical data.

Are there common misconceptions about Phlomis umbrosa?

It is often regarded as inherently safe based on traditional usage, but actual efficacy and safety must be confirmed via clinical trials.