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Pomella

Also known as: Pomella, pomegranate extract, Punica granatum L. (Pomella extract)

Overview

Pomella is a branded, standardized extract derived from the whole fruit of Punica granatum L., commonly known as pomegranate. It is specifically enriched in punicalagins, which are potent polyphenolic compounds. This botanical supplement is primarily utilized for its antioxidant and anti-inflammatory properties, contributing to potential benefits in skin health, gut microbiome modulation, and broader cardiovascular and urological health. While research on Pomella specifically is emerging, with a few recent randomized controlled trials, the broader body of evidence on pomegranate extracts, including systematic reviews, supports its diverse health applications. It is categorized as a polyphenol-rich botanical supplement.

Benefits

Pomella offers several evidence-based benefits. A 4-week randomized, double-blind, placebo-controlled trial (n=18) demonstrated that Pomella supplementation (75 mg punicalagins daily) significantly reduced facial wrinkle severity and forehead sebum production, indicating benefits for skin health. This study also revealed beneficial shifts in the gut microbiome, including an increase in beneficial bacteria like Faecalibacterium prausnitzii and Roseburia species, which are linked to anti-inflammatory effects. While not specific to Pomella, systematic reviews and meta-analyses of pomegranate juice have shown reductions in biomarkers of inflammation and vascular dysfunction, suggesting cardiovascular protective effects. Additionally, reviews indicate that pomegranate extracts can modulate inflammation, oxidative stress, and hypoxia pathways relevant to prostate health, with some clinical data supporting benefits in prostate cancer and benign prostatic hyperplasia management.

How it works

Pomella's primary mechanism of action stems from its bioactive components, punicalagins. These compounds act as potent antioxidants, neutralizing reactive oxygen species and mitigating oxidative stress throughout the body. They also modulate inflammatory pathways, specifically by reducing pro-inflammatory cytokines and inhibiting NF-κB signaling. Pomella influences the gut microbiome composition by promoting the growth of beneficial bacteria that produce short-chain fatty acids, which can exert systemic anti-inflammatory effects. Furthermore, the polyphenols present in the extract may contribute to improved endothelial function, supporting overall vascular health. It's important to note that the systemic effects of punicalagins may be mediated by their metabolites, such as urolithins, which are produced by gut bacteria.

Side effects

Pomella appears to have a favorable safety profile, with no serious adverse events reported in controlled clinical trials to date. Common side effects are not well-documented but are expected to be minimal given its natural origin and the doses typically used in studies. There have been no significant drug interactions or contraindications reported in the current literature. However, specific populations, such as pregnant or breastfeeding individuals and those with severe chronic diseases, have not been extensively studied. Therefore, caution is advised in these groups until more comprehensive safety data become available. As with any supplement, individuals with pre-existing medical conditions or those taking medications should consult a healthcare professional before starting Pomella supplementation.

Dosage

Effective doses of Pomella, based on current research, range from 75 mg to 250 mg of standardized punicalagins daily. A 4-week randomized controlled trial that demonstrated benefits for skin health and gut microbiome modulation utilized a dose of 75 mg of punicalagins daily. Higher doses, up to 250 mg, have also been studied for their effects on gut microbiome modulation. The optimal dosing beyond these studied ranges is not yet well-established, and further research is needed to determine long-term safety and efficacy at various dosages. Pomella is typically consumed in oral capsule form, and its bioavailability may be enhanced through metabolism by gut microbiota. Timing of dosage appears to be straightforward, with no specific recommendations for intake relative to meals.

FAQs

Is Pomella effective for skin aging?

Yes, a controlled clinical trial showed significant reduction in facial wrinkles and sebum production after 4 weeks of supplementation.

Does Pomella improve gut health?

Yes, research indicates it favorably modulates gut microbiota composition, increasing beneficial bacteria.

Is Pomella safe to take?

Current evidence suggests good safety at studied doses, with no serious adverse events reported in trials.

How soon can I expect to see effects from Pomella?

Skin benefits were observed within 4 weeks in one randomized controlled trial.

Is Pomella the same as pomegranate juice?

No, Pomella is a concentrated extract standardized for punicalagins, while pomegranate juice varies widely in composition.

Research Sources

https://pmc.ncbi.nlm.nih.gov/articles/PMC10778484/ – This randomized, double-blind, placebo-controlled trial (n=18) investigated the effects of Pomella (75 mg punicalagins/day) on skin health and the gut microbiome over 4 weeks. It found significant reductions in facial wrinkle severity and forehead sebum production, alongside beneficial shifts in gut bacteria like Faecalibacterium prausnitzii and Roseburia species, suggesting a gut-skin axis benefit.
https://www.nutritionaloutlook.com/view/pomella-pomegranate-extract-promotes-healthy-skin-and-gut-microbiome-study-shows – This article discusses the findings of a 4-week randomized, double-blind, placebo-controlled trial on Pomella. It highlights the significant reduction in facial wrinkle severity and forehead sebum production, as well as the positive modulation of the gut microbiome, including an increase in beneficial bacteria, supporting Pomella's role in skin and gut health.
https://pubmed.ncbi.nlm.nih.gov/32147056/ – This systematic review and meta-analysis evaluated the effects of pomegranate juice consumption on inflammatory and vascular dysfunction biomarkers. It concluded that pomegranate juice significantly reduces markers of inflammation and improves vascular function, suggesting its potential in cardiovascular disease prevention, though it did not specifically focus on Pomella extract.
https://onlinelibrary.wiley.com/doi/pdf/10.1155/2013/701434 – This narrative review explores the role of pomegranate extracts in urologic health, particularly in prostate cancer and benign prostatic hyperplasia. It summarizes evidence indicating that pomegranate's anti-inflammatory and antioxidant properties modulate pathways relevant to prostate health, supporting its potential as a complementary therapy.