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Poria Cocos Extract

Also known as: Fuling, Tuckahoe, *Poria cocos*

Overview

*Poria cocos*, also known as Fuling or Tuckahoe, is a medicinal fungus that has a long history of use in traditional Chinese medicine. It grows symbiotically on the roots of pine trees and is primarily utilized for its potential health benefits, particularly in promoting better sleep and enhancing immune function. The fungus is rich in bioactive compounds, including polysaccharides and triterpenoids, which contribute to its pharmacological properties. While the current evidence for *Poria cocos* is growing, it remains in the emerging stage, with a need for more high-quality randomized controlled trials (RCTs) and systematic reviews to validate its efficacy and safety. The supplement is available in various forms, including capsules and powders, making it accessible for a range of dietary practices.

Benefits

Research indicates that *Poria cocos* may improve sleep quality through its effects on GABA receptor activity, leading to reduced sleep latency and increased total sleep time. Notably, studies suggest significant improvement in sleep parameters, especially among individuals with sleep disorders or those undergoing chemotherapy. For cancer patients, *Poria cocos* may enhance the quality of life when used in conjunction with chemotherapy, potentially alleviating some side effects. However, the evidence is not yet comprehensive, necessitating further studies to define specific effect sizes and long-term benefits.

How it works

*Poria cocos* is believed to enhance the activity of GABA receptors, promoting inhibitory neurotransmission in the central nervous system, which is critical for sleep regulation. By modulating GABA-induced chloride currents, it helps facilitate the onset and maintenance of sleep. While its exact absorption and bioavailability characteristics are not well-documented, its interaction with the central nervous system is significant in mediating its sleep-promoting effects.

Side effects

Overall, *Poria cocos* is generally regarded as safe, although comprehensive safety data is limited. Common side effects are not well-documented; however, sporadic reports of gastrointestinal disturbances may occur. Rare side effects have insufficient data, highlighting the need for caution. Potential interactions with sedatives or other central nervous system depressants should be monitored. Currently, there are no well-documented contraindications, yet pregnant or breastfeeding individuals should exercise caution due to the lack of definitive safety studies in these populations.

Dosage

The minimum effective dose of *Poria cocos* has not been established; however, animal studies suggest potential benefits at doses of 40 mg/kg or more. As optimal dosage ranges are yet undetermined in humans, it is advised to typically take *Poria cocos* before bedtime for sleep benefits. The supplement is available in both capsule and powder forms, and specifics regarding absorption factors are limited. Currently, there are no defined upper limits or safety thresholds for human consumption.

FAQs

What is the best way to use *Poria cocos*?

It is best used under medical supervision due to limited safety data and possible interactions with other medications.

When should I take *Poria cocos*?

For optimal sleep benefits, it is recommended to take *Poria cocos* before bedtime.

Can *Poria cocos* replace my current medications?

No, it should not be used as a substitute for prescribed medications without consulting a healthcare provider.

Is *Poria cocos* safe during pregnancy?

Caution is advised as comprehensive safety data for pregnant or breastfeeding women is lacking.

What results can I expect from using *Poria cocos*?

Users typically report improved sleep quality, but results may vary and require time to manifest.

Research Sources

https://www.mdpi.com/1660-4601/19/11/6629 – This study examines the effects of *Poria cocos* on sleep quality and mechanisms of action, highlighting its role in enhancing GABA-induced chloride currents. Findings indicate improvement in sleep parameters, though human trials are lacking.
https://libraryinfo.bhs.org/systematicreviews – A systematic review discussing the efficacy of *Poria cocos*-based formulas in improving quality of life for ovarian cancer patients undergoing chemotherapy. Evidence suggests benefits of adjunctive therapy.
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.788810/full – This systematic review assesses the combined effects of *Poria cocos* and hypoglycemic agents in managing type 2 diabetes, suggesting potential advantages in formulation but limited focus on *Poria cocos* alone.
https://jmla.pitt.edu/ojs/jmla/article/download/246/1489 – An article focusing on the pharmacological effects of traditional medications, including *Poria cocos*, and their role in sleep enhancement, providing insights into their mechanisms and limitations.
https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0278536 – A meta-analysis reviewing the cancer care applications of *Poria cocos*, evaluating its impact when used as an adjunct treatment, and emphasizing the need for further research into monotherapy.