Get Your Personalized Supplement StackSupplement Stack Quiz

Rutin Extract

Also known as: Rutin, Rutin Extract, Hydroxyethylrutosides

Overview

Rutin is a flavonoid glycoside abundant in various plants, such as apples, citrus fruits, and cranberries. It consists of quercetin and rutinose, and it is recognized for its antioxidant, anti-inflammatory, and immunomodulatory properties. Rutin has garnered interest in clinical research for its potential to enhance blood pressure regulation, improve antioxidant levels, and ameliorate conditions like chronic venous insufficiency (CVI). With several randomized controlled trials and systematic reviews available, the overall research maturity level is moderate, although some studies indicate limitations in sample size and quality, highlighting the necessity for further research.

Benefits

Rutin has been associated with several health benefits. Evidence suggests significant blood pressure reduction in patients with type 2 diabetes mellitus (T2DM), with systolic blood pressure dropping from 129.44 mmHg to 120.84 mmHg after treatment. Additionally, it has been shown to enhance antioxidant enzyme activity, improving antioxidant status in this population. Lifestyle quality is also positively affected, with improvements noted in emotional and general health. For patients with CVI, hydroxyethylrutosides derived from rutin significantly alleviate symptoms like pain and heaviness in the legs. These benefits are notably pronounced in patients with T2DM and CVI, as corroborated by meta-analysis findings.

How it works

Rutin operates primarily through its antioxidant and anti-inflammatory effects. It enhances activities of key antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx). Rutin also plays a role in modulating immune responses and improving vascular function, contributing to better blood pressure regulation. It acts on molecular pathways involved in oxidative stress, targeting inflammatory cytokines to reduce inflammation, ultimately promoting cardiovascular health.

Side effects

Rutin is generally recognized as safe, with no significant side effects reported in available studies. Common side effects (>5%) were not observed, while uncommon and rare side effects are also absent. However, potential interactions with blood thinners and other blood pressure-affecting medications should be noted. While no specific contraindications are extensively documented, caution is advised for individuals with bleeding disorders or on anticoagulant therapy, as a preventive measure. Pregnant or breastfeeding women should consult health care providers due to insufficient safety data in these groups.

Dosage

The minimum effective dose of rutin has not been firmly established; however, various clinical trials have utilized doses between 500 mg and 1000 mg daily. An optimal dosing range for achieving blood pressure and antioxidant benefits lies within this spectrum, with studies showing effective outcomes supporting these dosages. Although a maximum safe dose is not definitively outlined, daily intake up to 1000 mg is generally tolerated well without significant adverse effects. Rutin can be safely consumed at any time of day, ideally with meals to enhance absorption and can be found in capsule or tablet form.

FAQs

Is Rutin safe to take?

Yes, rutin is generally safe for most individuals; however, those with specific health conditions or on certain medications should consult a healthcare provider.

When should I take Rutin?

Rutin can be taken at any time of day, though it is often advised to take it with meals to enhance its absorption.

What results can I expect?

You may notice improvements in blood pressure, antioxidant levels, and overall quality of life, although individual responses can vary.

Is Rutin a cure for my condition?

No, rutin should not be considered a cure but may serve as a beneficial adjunct to standard treatments.