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Sacred Lotus Seed Extract

Also known as: Nelumbo nucifera (Gaertn.), Sacred lotus seed extract, Lotus seed extract, Nelumbo seed extract, Nelumbo nucifera

Overview

Sacred lotus seed extract is derived from the seeds of *Nelumbo nucifera*, an aquatic plant native to Asia and Australia. It is characterized by a rich profile of bioactive phytochemicals, including flavonoids, alkaloids, phenolic acids, and polysaccharides such as quercetin, kaempferol, and isoquercitrin. The extract is primarily used for its antioxidant and anti-inflammatory properties, with emerging applications in anti-aging and cognitive support. It is also being explored in topical formulations for skin health. Research on lotus seed extract is moderately mature, with robust preclinical and in vitro studies, but clinical trials in humans are limited. While preclinical evidence is strong, clinical evidence is promising but requires further validation through large-scale, randomized controlled trials to confirm its efficacy and safety in humans.

Benefits

Lotus seed extract exhibits significant antioxidant activity, demonstrated by ABTS values up to 14.35 mg AAE/g and FRAP values up to 2.30 mg AAE/g in seed cotyledon and embryo. In vitro and animal studies suggest anti-inflammatory effects, showing a dose-dependent reduction in inflammatory markers, although human data are limited. Animal studies also indicate potential cognitive support, but human RCTs are needed to confirm these findings. Additionally, the extract contains compounds that may reduce symptoms of skin aging in preclinical models. While the general antioxidant and anti-inflammatory effects may benefit aging or stressed individuals, more research is needed to identify specific population benefits and establish clinical effect sizes in humans. The time course of these benefits is not well characterized in humans, but preclinical data suggest effects may be observed within days to weeks.

How it works

The primary mechanisms of action of sacred lotus seed extract involve its antioxidant and anti-inflammatory properties. As an antioxidant, it scavenges free radicals through its phenolic compounds and flavonoids. Its anti-inflammatory effects are mediated by modulating NF-κB and cytokine pathways, which reduces the production of pro-inflammatory mediators. The extract primarily affects oxidative stress and inflammation, with potential neuroprotective and skin health benefits. Key molecular targets include NF-κB, reactive oxygen species (ROS), and inflammatory cytokines. Animal studies suggest good absorption of phenolic compounds, but the exact bioavailability in humans is not yet fully understood.

Side effects

Sacred lotus seed extract is generally recognized as safe based on traditional use and limited clinical data. No major safety concerns or common, uncommon, or rare side effects have been reported in available studies. There are no known significant drug interactions, although a theoretical risk exists with anticoagulants due to the antiplatelet activity of flavonoids. Caution is advised in individuals with known allergies to lotus or related plants. Due to insufficient data, use with caution in pregnant or lactating women. Overall, the safety profile appears favorable, but further research is needed to comprehensively assess potential adverse effects in diverse populations.

Dosage

The minimum effective dose of sacred lotus seed extract has not been established in humans. Animal studies have used doses equivalent to 100–500 mg/kg body weight, but human equivalents are unclear. Typical supplement doses range from 100–500 mg/day, extrapolated from preclinical data. The maximum safe dose is also not established, as no toxicity has been reported in available studies. There are no specific timing recommendations, but taking the extract with meals may enhance the absorption of fat-soluble compounds. It is available in capsules, powders, and topical gels, with both oral and topical forms showing bioactivity. Absorption may be enhanced by dietary fats due to the presence of fat-soluble antioxidants. No required cofactors have been identified.

FAQs

Is there enough evidence to support the benefits of sacred lotus seed extract?

Most evidence is preclinical, with limited human clinical data. Effects in humans are plausible but not conclusively proven. More human studies are needed.

Are there any safety concerns with taking sacred lotus seed extract?

No major safety concerns have been reported. However, monitor for allergic reactions. Pregnant or breastfeeding women should use it with caution.

When is the best time to take sacred lotus seed extract?

It may be taken at any time of day. Taking it with meals may improve absorption, especially due to the presence of fat-soluble antioxidants.

What results can I expect from taking sacred lotus seed extract?

Antioxidant and anti-inflammatory effects are likely, but cognitive and anti-aging benefits are less certain in humans. Results may be modest.

Is sacred lotus seed extract a cure-all?

No, it is not a cure-all. Benefits are primarily related to reducing oxidative stress and inflammation, and should be considered as part of a broader health strategy.

Research Sources

https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2022.1022794/full – This study investigates the antioxidant and anti-inflammatory properties of lotus seed extract. It provides evidence for the extract's potential in reducing oxidative stress and inflammation, supporting its use as a dietary supplement.
https://www.jstor.org/stable/2445863 – This resource provides botanical information about Nelumbo nucifera, including its traditional uses and chemical constituents. It offers a foundation for understanding the plant's historical applications and potential health benefits.
https://onlinelibrary.wiley.com/doi/10.1155/2015/789124 – This review discusses the anti-aging and neuroprotective compounds found in lotus seed extract. It highlights the antioxidant and anti-inflammatory effects, suggesting potential benefits for cognitive function and skin health.
https://he01.tci-thaijo.org/index.php/CMMJ-MedCMJ/article/view/268549 – This article likely explores the medicinal properties of lotus seeds within the context of traditional Thai medicine. It may provide insights into the historical use of lotus seeds for various health conditions.
https://pubs.acs.org/doi/10.1021/acsomega.1c07018 – This study focuses on the phytochemical and antioxidant profiling of lotus seed components. It identifies the phenolic compounds present and quantifies the high antioxidant capacity of the extract, supporting its potential health benefits.