Ferrochel
Also known as: Iron bisglycinate, Ferrochel, Iron bisglycinate chelate, Ferrous bisglycinate
Overview
Ferrous bisglycinate is a synthetic compound formed by chelating iron with two glycine molecules, which enhances its bioavailability while minimizing gastrointestinal side effects. Primarily utilized as a dietary supplement, it is commonly recommended for the prevention and treatment of iron deficiency anemia in populations such as pregnant women and children. While not naturally occurring, its high bioavailability makes it a preferred choice for iron supplementation compared to traditional iron salts. The current research maturity level is moderate, with several randomized controlled trials (RCTs) and meta-analyses corroborating its efficacy in improving iron levels and reducing adverse events. Overall, the evidence gathered is of good quality, yet additional studies focusing on diverse populations are warranted.
Benefits
Ferrous bisglycinate presents several evidence-based benefits, particularly for increasing hemoglobin levels and reducing gastrointestinal adverse events in pregnant women. A meta-analysis demonstrated that its supplementation led to higher hemoglobin concentrations compared to other iron supplements, recording a standardized mean difference of 0.54 g/dL (95% CI, 0.15-0.94; P < 0.01), alongside a notable 64% lower rate of gastrointestinal side effects. Although it may also improve ferritin levels, the evidence in this area is inconsistent. Most documented benefits apply to pregnant women, indicating a significant clinical relevance due to the observed hemoglobin improvement and side effect reduction. Benefits typically appear within weeks of initiating supplementation.
How it works
Ferrous bisglycinate enhances iron absorption through the formation of a stable chelate that survives intact through the gastrointestinal tract, thereby increasing bioavailability. This chelation allows for better absorption of iron, which is essential for erythropoiesis—the production of red blood cells. While specific molecular targets remain unidentified, the chelate significantly influences iron metabolism and supports the body's hematopoietic system, ensuring an adequate supply of iron for red blood cell production.
Side effects
The overall safety profile of ferrous bisglycinate is generally favorable, as it is recognized as generally safe (GRAS) by the FDA for use in food enrichment and fortification. Compared to traditional iron supplements, it demonstrates a markedly lower incidence of gastrointestinal side effects, which are more common with alternatives like ferrous sulfate. While uncommon side effects aren't well documented, they are likely similar to those associated with other iron supplements. Rare side effects have not been commonly reported. Although significant drug interactions have not been noted, caution is advised when concurrently using other minerals or medications. In terms of contraindications, there are no specific red flags, but care should be taken in individuals with iron overload conditions or hemochromatosis. Given its favorable safety profile, particularly for pregnant women and children, it is a recommended option for iron supplementation.
Dosage
For optimal results, ferrous bisglycinate is generally recommended in daily doses ranging from 15 mg to 40 mg of elemental iron, with a minimum effective dose typically set at approximately 15 mg. While the maximum safe dose has not been precisely established, studies indicate that higher doses, exceeding 500 mg/kg in animal studies, did not yield adverse effects. To enhance absorption, it is best taken on an empty stomach, ideally accompanied by water. Ferrochel is particularly recommended for its high bioavailability and minimal side effects. Furthermore, while no specific cofactors are required for absorption, vitamin C may additionally enhance iron uptake, should be considered in dietary practices.
FAQs
How should Ferrochel be taken for best results?
Ferrochel is best taken on an empty stomach to maximize absorption, ideally with water.
Is Ferrochel safe for everyone?
Generally safe, but individuals with conditions of iron overload should avoid it.
When should I take Ferrochel?
It is recommended to take Ferrochel with water, ideally on an empty stomach.
What results can I expect from using Ferrochel?
Users can expect improved hemoglobin levels and fewer side effects compared to traditional iron supplements.
Is Ferrochel a natural source of iron?
No, it is a synthetic compound designed to enhance iron bioavailability.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/36728680/ – A systematic review and meta-analysis assessing the effects of ferrous bisglycinate supplementation found it significantly increased hemoglobin levels and reduced gastrointestinal adverse events in pregnant women and children.
- https://pubmed.ncbi.nlm.nih.gov/11688078/ – A randomized controlled trial comparing iron bisglycinate chelate (Ferrochel) with ferrous sulfate showed that Ferrochel was more effective at increasing hemoglobin, even at lower dosages, and resulted in fewer gastrointestinal side effects.
- https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2786031 – This research further supports the efficacy and safety of using ferrous bisglycinate as an iron supplement, particularly in vulnerable populations such as pregnant women.
Supplements Containing Ferrochel
Easy Iron 25 mg
Country Life
Iron Complex
NOW
My Favorite Multiple Energizer
Natrol
OB Complete 400
Vertical Pharmaceuticals
My Favorite Multiple Original Multivitamin
Natrol
High Absorption Iron with Ferrochel 27 mg
Doctor's Best
Prenatal Essentials
XYMOGEN
Mega B-12 Daily Vits
NOW
Women's Multi with Iron
Altrum
Daily Best Prenatal with Probiotics
DaVinci Laboratories