Pepzingi
Also known as: Zinc L-carnosine, Polaprezinc, Pepzin Gi, Zinc-carnosine
Overview
Zinc-carnosine, commonly referred to as Pepzin Gi, is a chelate formed from zinc and the dipeptide carnosine. While it is not found naturally in food, it is synthesized for therapeutic use in both pharmaceutical and dietary supplement forms. This supplement is primarily recognized for its gastrointestinal protective effects, serving particularly well in treating conditions like gastric ulcers and gastritis. Studies have demonstrated its ability to promote mucosal healing and provide protective effects within the gastrointestinal tract. Research on zinc-carnosine is moderately developed, with clinical trials and observational studies attesting to its efficacy and safety, although it's less extensively studied than some other dietary supplements.
Benefits
Zinc-carnosine has noteworthy benefits, particularly in gastrointestinal health. Clinical trials show it can significantly enhance the healing of gastric ulcers, with evidence indicating substantial improvement in healing rates compared to placebo. It's also associated with mucosal healing, providing relief for individuals with gastritis. Additional effects of zinc-carnosine include potential anti-inflammatory properties and antioxidant action, though evidence in these areas is less robust. Patient populations benefiting most include those suffering from gastric ulcers and gastritis, where the supplement has demonstrated its clinical significance. Typically, benefits are observed within a few weeks to months of treatment initiation.
How it works
Zinc-carnosine exerts its effects primarily by protecting the gastric mucosa and promoting its healing. It appears to enhance mucosal defense mechanisms and may have anti-inflammatory and antioxidative activities, contributing to its therapeutic effects in the gastrointestinal system. The specific molecular targets involved in its mechanism are not fully understood, yet it is believed to engage with various cellular components that are crucial for mucosal protection and healing. Furthermore, zinc-carnosine is generally well-absorbed orally, enhancing its availability for therapeutic action.
Side effects
Zinc-carnosine is generally regarded as safe when used as directed, but certain adverse effects may occur. Mild gastrointestinal symptoms, including nausea, diarrhea, and stomach discomfort, are common (occurring in over 5% of users). Uncommon side effects include allergic reactions (1-5%), though severe allergic responses are rare (<1%). The supplement may interact with certain medications and should be used cautiously in individuals with known zinc deficiencies or those on specific drug regimens that pose risk. Pregnant or breastfeeding women should consult a healthcare provider before use. Long-term use and high doses may increase the risk of adverse effects.
Dosage
The recommended daily dosage for zinc-carnosine typically ranges from 75 to 300 mg, divided into multiple doses. A minimum effective dose is often around 75-150 mg per day, but higher doses might be necessary depending on the severity of the gastrointestinal condition being treated. While some sources suggest a maximum safe dose of 300 mg per day, it is advisable to seek medical advice before exceeding this limit. To optimize absorption and minimize gastrointestinal side effects, zinc-carnosine is best taken with meals. It is available in both capsule and tablet forms, with no significant differences in efficacy between these formats.
FAQs
Is zinc-carnosine safe for long-term use?
Zinc-carnosine is generally considered safe for long-term use, but it should be monitored by a healthcare provider to avoid potential adverse effects.
When is the best time to take zinc-carnosine?
It is recommended to take zinc-carnosine with meals to minimize gastrointestinal side effects.
How long does it take to see results from zinc-carnosine?
Most patients notice improvements in gastric ulcer healing and gastritis symptoms within a few weeks to a few months of starting supplementation.
Can zinc-carnosine be used as a solution for all gastrointestinal issues?
No, zinc-carnosine is not a cure-all and should be used under medical guidance for specific conditions.
Research Sources
- https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2761273 – This clinical trial illustrates that zinc-carnosine significantly improves gastric ulcer healing rates compared to placebo, with over 100 participants reporting statistically significant healing (p < 0.05).
- https://onlinelibrary.wiley.com/doi/abs/10.1002/jpn3.12115 – The study discusses the efficacy of zinc-carnosine in treating gastritis, showing comparable or superior results to standard treatments.
- https://f1000research.com/articles/13-790 – Observational studies have shown positive outcomes in patients with gastritis and ulcers when zinc-carnosine is included in treatment regimens, notably concerning symptom relief.
Supplements Containing Pepzingi
Healthy Gut Mint
Terra Origin
Healthy Gut Matcha Green Tea
Terra Origin
Healthy Gut Capsules With Vitamin D
Terra Origin
Healthy Gut Fennel
Terra Origin
Healthy Gut Mint
Terra Origin
Healthy Gut Peach Banana
Terra Origin
Healthy Gut Capsules
Terra Origin
Healthy Gut Berry
Terra Origin
Healthy Gut Berry
Terra Origin
Healthy Gut Capsules with Vitamin D
Terra Origin
Healthy Gut Honey Lemon
Terra Origin
Healthy Gut Matcha Green Tea
Terra Origin