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Sesame Seed Lignan Extract

Also known as: Sesamum indicum, sesamin, sesamolin, sesaminol, sesame extract, sesame oil, Sesame Seed Lignan Extract

Overview

Sesame (*Sesamum indicum*) is a flowering plant cultivated primarily in tropical and subtropical regions, known for its nutrient-dense seeds and oil. Rich in lignans such as sesamin, sesamolin, and sesaminol, these compounds are celebrated for their antioxidant and anti-inflammatory properties. Sesame lignans are available in various forms, including whole seeds, oils, and concentrated extracts, and have applications in dietary and cosmetic products. Research indicates that these lignans may help mitigate risk factors for chronic diseases, improve lipid profiles, and reduce oxidative stress. Sesame lignan supplements are becoming increasingly important for enhancing health, particularly in relation to cardiovascular disease prevention.

Benefits

Clinical studies have demonstrated significant cardiovascular benefits from sesame lignans, such as a decrease in total cholesterol levels by approximately 10.89 mg/dl and a reduction in LDL cholesterol by about 8.43 mg/dl. Reductions in systolic blood pressure averaging 3.66 mmHg have also been observed. Furthermore, evidence supports improvements in glycemic control among individuals with metabolic disorders, leading to lower fasting blood glucose and HbA1c levels. Regular consumption can significantly enhance health outcomes, particularly for individuals at risk for cardiovascular and metabolic diseases, supported by robust clinical trials affirming these benefits.

How it works

Sesame lignans exert their beneficial effects by modulating lipid metabolism and providing antioxidant protection. They influence key enzymes involved in the synthesis and degradation of lipids, resulting in improved lipid profiles. Additionally, by reducing oxidative stress, sesame lignans play a crucial role in maintaining cardiovascular health and supporting essential metabolic processes in the body.

Side effects

Generally recognized as safe for most individuals, sesame lignans report significant adverse effects in less than 5% of cases. Those with sesame allergies should avoid these supplements to prevent serious allergic reactions. While notable drug interactions are uncommon, individuals with chronic health conditions are encouraged to start with lower dosages to monitor tolerance. Pregnant or breastfeeding women are advised to seek medical consultation before use due to potential safety concerns. The low occurrence of adverse effects contributes to the rising acceptance of sesame lignans as a dietary supplement.

Dosage

The typical recommended dosage of sesame lignans ranges between 50 to 200 mg per day, with many experts suggesting a daily intake of 100 to 200 mg for noticeable health benefits. Although specific upper limits for sesame lignan consumption have yet to be established, further research is warranted to ascertain the safety of higher doses. To optimize absorption, it is recommended to consume sesame lignans with meals, as bioavailability may vary depending on whether they are taken in the form of whole seeds, oil, or concentrated extracts.

FAQs

Are sesame lignans safe to take?

Yes, sesame lignans are generally considered safe, but individuals with sesame allergies should avoid them.

When is the best time to take sesame lignans?

While there are no specific timing guidelines, taking sesame lignans with meals may enhance absorption.

What benefits should I expect from sesame lignans?

Users can expect improvements in blood lipid profiles, reduced blood pressure, and potential benefits in glycemic control.

Are all sesame products equally effective?

No, the effectiveness and bioavailability can vary between different sesame products depending on their form and processing.

Research Sources

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694004/ – This article examines the effects of sesame lignans on cardiovascular health, highlighting considerable reductions in cholesterol levels and blood pressure. The study utilized a meta-analysis approach to synthesize findings from multiple clinical trials, reinforcing the effectiveness of sesame lignans in promoting heart health.
https://www.sciencedirect.com/science/article/pii/S0899900717310518 – This research provides insight into the antioxidant properties of sesame lignans and their potential to improve metabolic health. The study outlines the role of lignans in modulating lipid metabolism and their implications for conditions like diabetes and heart disease.