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Sesame Seed Lignan Extract

Also known as: Sesame lignans, sesame seed extract, Sesame Seed Lignan Extract

Overview

Sesame seed lignan extract is derived from sesame seeds (Sesamum indicum), recognized for its rich content of furofuran lignans, including sesamin, sesamolin, and sesaminol glucosides. This dietary supplement is often used to harness potential health benefits such as improved lipid profiles, reduced blood pressure, and potent antioxidant effects. The extract exhibits significant antioxidant, anti-inflammatory, and lipid-modulating properties. While moderate research has been conducted on its efficacy, the overall quality of evidence remains mixed, highlighting notable benefits in lipid management and blood pressure regulation, though further studies are warranted for a more comprehensive understanding of its mechanisms and effects.

Benefits

Evidence-based benefits of sesame seed lignan extract include a reduction in total cholesterol (TC) by approximately -10.89 mg/dl and a decrease in LDL-cholesterol by -8.43 mg/dl, alongside a reduction in systolic blood pressure by -3.66 mmHg. These outcomes are particularly significant for populations with hypertension or dyslipidemia. Additional reported benefits pertain to its antioxidant properties; however, quantification in human subjects is less prevalent. The time course for achieving these benefits is not well-delineated but typically spans several weeks to months of supplementation. Some systematic reviews indicate notable effects, though the clinical significance may vary.

How it works

The mechanism of action for sesame lignan extract primarily involves modulation of fatty acid metabolism and inhibition of cholesterol absorption. These lignans demonstrate interactions with biological pathways related to cardiovascular health, notably improving lipid profiles and lowering blood pressure. Key molecular targets include acyl-CoA reductase, influencing lipid metabolism pathways. Although the absorption and bioavailability of sesame lignans have not been rigorously studied, they are generally perceived to be well-absorbed dietary components.

Side effects

Sesame seed lignan extract is generally considered safe, with most studies reporting no significant side effects. Common side effects are not consistently documented, and acute adverse reactions are rare. Limited evidence suggests potential interactions with cholesterol-lowering medications, and no contraindications have been established. However, special consideration should be given to pregnant or breastfeeding women, as the data regarding safety in these populations is limited. Overall, individuals should consult healthcare providers when combining this extract with other medications, especially those affecting lipid metabolism.

Dosage

The effective dosage of sesame seed lignan extract has not been definitively established, but findings from various studies suggest a typical range of 100 to 200 mg of sesamin per day. There are no specific timing recommendations for its ingestion. Notably, absorption of the extract may be enhanced when consumed alongside fatty meals. Although maximum safe dosage limits remain unspecified, practitioners recommend starting with lower doses to assess tolerance. No required cofactors have been outlined, further simplifying its use in dietary regimens.

FAQs

Is sesame lignan extract safe to use?

Yes, sesame lignan extract is generally recognized as safe, but individuals should consult with healthcare providers, especially if combining with other medications.

How long does it take to see results from sesame lignan extract?

Results can vary, but many studies report benefits within several weeks to months of consistent supplementation.

Can sesame lignan extract replace my medication?

No, it should not replace medical treatments but can be used as a supplement to support health along with medical advice.

What are the primary health benefits?

Primary benefits include improved lipid profiles and lower blood pressure, along with antioxidant effects.

Are there any known side effects?

Most studies report no significant side effects, but some may experience rare interactions with cholesterol-lowering drugs.

Research Sources

  • https://pubmed.ncbi.nlm.nih.gov/35311241/ – This systematic review and meta-analysis of 212 participants indicated that sesame lignan supplementation significantly reduced total cholesterol, LDL-cholesterol, and systolic blood pressure. Although clinically significant effects were observed, sample sizes varied, indicating a need for further research.
  • https://pubmed.ncbi.nlm.nih.gov/21114470/ – This systematic review reviewed 908 participants across ten trials and suggested that while sesame consumption did not lead to significant total cholesterol reductions, it did lower triglycerides. The review noted high heterogeneity and inconsistent results across studies.
  • https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/sesame-fractions-and-lipid-profiles-a-systematic-review-and-metaanalysis-of-controlled-trials/25D054D457893E57A9D4EA8EBF8459A3 – In another systematic review, sesame fractions were assessed for their lipid-modulating effects. Findings supported the antioxidant properties of sesame lignans but lacked detailed quantitative data on the extent of benefits, emphasizing the need for further studies in humans.

Supplements Containing Sesame Seed Lignan Extract

Super Omega-3 Plus by Life Extension
88

Super Omega-3 Plus

Life Extension

Score: 88/100
Once-Daily Health Booster by Life Extension
63

Once-Daily Health Booster

Life Extension

Score: 63/100
Life Extension Mix Capsules by Life Extension
65

Life Extension Mix Capsules

Life Extension

Score: 65/100
Super CLA Blend With Guarana & Sesame Lignans by Life Extension
63

Super CLA Blend With Guarana & Sesame Lignans

Life Extension

Score: 63/100
Life Extenstion Mix Capsules by Life Extension
63

Life Extenstion Mix Capsules

Life Extension

Score: 63/100
Life Extenstion Mix Capsules by Life Extension
53

Life Extenstion Mix Capsules

Life Extension

Score: 53/100
Life Extenstion Mix Tablets by Life Extension
60

Life Extenstion Mix Tablets

Life Extension

Score: 60/100
Life Extenstion Mix Powder by Life Extension
58

Life Extenstion Mix Powder

Life Extension

Score: 58/100
Life Extenstion Mix Tablets With Extra Niacin by Life Extension
58

Life Extenstion Mix Tablets With Extra Niacin

Life Extension

Score: 58/100
Life Extenstion Mix Capsules Without Copper by Life Extension
60

Life Extenstion Mix Capsules Without Copper

Life Extension

Score: 60/100
Life Extenstion Mix Tablets Without Copper by Life Extension
65

Life Extenstion Mix Tablets Without Copper

Life Extension

Score: 65/100
Life Extenstion Mix Powder Without Copper by Life Extension
60

Life Extenstion Mix Powder Without Copper

Life Extension

Score: 60/100

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