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Sesame Seed Lignan Extract

Also known as: Sesame lignans, Sesame seed extract, Sesamolin, Sesaminol glucosides, Sesame seed lignan extract, Sesamin

Overview

Sesame seed lignan extract is derived from sesame seeds (Sesamum indicum) and is rich in furofuran lignans, including sesamin, sesamolin, and sesaminol glucosides. It is primarily used as a dietary supplement for its potential health benefits, such as improving lipid profiles, reducing blood pressure, and providing antioxidant effects. Sesame lignans are known for their antioxidant, anti-inflammatory, and lipid-modulating properties. Research on sesame lignans is moderately mature, with several human studies exploring their effects, although more comprehensive research is needed. The available evidence presents mixed results, with some systematic reviews indicating significant improvements in lipid profiles and blood pressure, while others report inconsistent outcomes. These lignans are often consumed as part of sesame oil or seed extracts.

Benefits

Sesamin supplementation has demonstrated potential benefits in reducing total cholesterol (TC) by approximately -10.89 mg/dl, LDL-cholesterol by -8.43 mg/dl, and systolic blood pressure by -3.66 mmHg. These effects are statistically significant but may not be clinically significant for all individuals. Additionally, sesame lignans exhibit antioxidant and potential anti-aging effects, though these are less quantified in human studies. Individuals with hypertension or dyslipidemia may particularly benefit from sesame lignan supplementation. The duration required to achieve these benefits is not definitively established, but studies typically range from several weeks to months. Overall, while promising, further research is needed to fully understand the scope and consistency of these benefits across diverse populations.

How it works

Sesame lignans primarily function by modulating fatty acid metabolism, inhibiting cholesterol absorption, and exerting antioxidant effects. They interact with the cardiovascular system, leading to improvements in lipid profiles and reductions in blood pressure. At the molecular level, sesame lignans are known to inhibit acyl-CoA reductase and modulate lipid metabolism pathways. While the bioavailability of sesame lignans has not been extensively studied, they are generally considered to be well-absorbed when consumed as part of sesame oil or seeds. These mechanisms collectively contribute to the observed health benefits associated with sesame lignan consumption.

Side effects

Sesame seed lignan extract is generally considered safe, with no significant side effects consistently reported in most studies. Common or uncommon side effects are not well-documented. Rare side effects are also not well-documented. There is a potential for interactions with cholesterol-lowering medications, although the evidence is limited. No specific contraindications have been established. Pregnant or breastfeeding women should consult healthcare providers before using sesame lignan extract due to limited safety data in these populations. Overall, while sesame lignans appear to be safe for most individuals, caution and consultation with a healthcare professional are advised, especially for those with pre-existing conditions or taking medications.

Dosage

While a minimum effective dose of sesamin is not well-established, typical doses used in studies range from 100 to 200 mg per day. Optimal dosage ranges and maximum safe doses are not clearly defined. There are no specific timing recommendations for sesame lignan extract consumption. It is often consumed as part of sesame oil or seed extracts. Absorption may be enhanced when consumed with fatty meals. No required cofactors have been established. Due to the lack of comprehensive data on optimal and safe dosages, it is advisable to start with a lower dose and consult with a healthcare professional to determine the most appropriate dosage for individual needs and health conditions.

FAQs

Is sesame lignan extract safe to use with other medications?

Sesame lignan extract is generally safe, but caution is advised when combined with other medications, particularly cholesterol-lowering drugs. Consult with a healthcare provider to ensure there are no potential interactions.

What are the expected results from taking sesame lignan extract?

Sesame lignan extract may lead to potential improvements in lipid profiles and blood pressure. However, it is not a substitute for medical treatment and should be used as a dietary supplement.

Are there any specific timing recommendations for taking sesame lignan extract?

There are no specific timing recommendations for taking sesame lignan extract. It can be taken at any time of day, preferably with a meal to enhance absorption.

What are the long-term effects of using sesame lignan extract?

There is limited data on the long-term effects of sesame lignan extract use, particularly in special populations. More research is needed to fully understand its long-term safety and efficacy.

Research Sources

https://pubmed.ncbi.nlm.nih.gov/35311241/ – A systematic review and meta-analysis involving 212 participants across seven trials found that sesamin supplementation significantly reduced total cholesterol, LDL-cholesterol, and systolic blood pressure. The study's limitations include a limited sample size and variability in study durations, resulting in a moderate quality assessment.
https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/sesame-fractions-and-lipid-profiles-a-systematic-review-and-metaanalysis-of-controlled-trials/25D054D457893E57A9D4EA8EBF8459A3 – A systematic review and meta-analysis of ten trials with 908 participants examined the effects of sesame consumption on lipid profiles. The study found that sesame consumption did not significantly reduce total cholesterol but did lower triglycerides. High heterogeneity among the studies was noted, leading to a moderate quality assessment.
https://pubmed.ncbi.nlm.nih.gov/21114470/ – This review provides a comprehensive overview of the biological activities of sesame lignans, highlighting their antioxidant and lipid-modulating effects. While it offers valuable insights into the mechanisms of action, it lacks quantitative data from primary research studies, limiting its ability to provide specific, quantifiable outcomes.
https://www.mdpi.com/1420-3049/26/4/883 – This source discusses the antioxidant properties of sesame lignans and their potential health benefits. It provides a detailed overview of the molecular mechanisms through which these compounds exert their effects, supporting their use as a dietary supplement.